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BMS673 Topics In Molecular Biology UITM Assignment Answer Malaysia 

BMS673 Topics in Molecular Biology is an advanced course at UITM Malaysia that enables students to apply their knowledge and skills from previous semesters to assess and analyze scientific reports, services, or solutions created using molecular biology tools. 

The BMS673 course involves a combination of distance learning and interactive sessions with assigned lecturers. Students will engage in intensive literature surveys, critical reading, and submit reading reports, culminating in an oral presentation of their findings.

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Assignment Brief 1 : Extract and explain the core points from a scientific review article on a topic/ subject in molecular biology

Advancements in Gene Editing Technologies for Molecular Biology Research”

Introduction: 

The review article discusses recent advancements in gene editing technologies and their applications in molecular biology research. The primary focus is on three major gene editing techniques: CRISPR-Cas9, TALENs, and ZFNs.

Core Points:

  • CRISPR-Cas9: The review highlights CRISPR-Cas9 as a revolutionary gene editing tool due to its simplicity, efficiency, and versatility. It works by utilizing a guide RNA to target specific DNA sequences and Cas9 protein to cleave the DNA. Researchers have successfully employed CRISPR-Cas9 to modify genes, study gene function, and investigate disease mechanisms.
  • TALENs (Transcription Activator-Like Effector Nucleases): This technique involves custom-designed nucleases that can also target specific DNA sequences. TALENs are known for their precision and effectiveness in gene editing. While not as widely adopted as CRISPR-Cas9, they offer an alternative approach, especially in cases where CRISPR faces challenges, such as off-target effects.
  • ZFNs (Zinc Finger Nucleases): ZFNs were among the first gene editing tools developed. They use engineered zinc finger proteins to target DNA sequences, followed by a nuclease domain that cleaves the DNA. While effective, ZFNs are more complicated to design and implement compared to CRISPR-Cas9 and TALENs, limiting their widespread use.
  • Applications in Molecular Biology: The review article discusses various applications of gene editing technologies in molecular biology research. These include creating genetically modified organisms (GMOs), developing disease models, investigating gene function, and potential gene therapies for genetic disorders.
  • Challenges and Ethical Considerations: The review emphasizes the need for careful consideration of ethical issues surrounding gene editing, such as off-target effects, unintended consequences, and the potential for germline editing. Researchers and policymakers must strike a balance between scientific progress and responsible use.

Conclusion: 

The review article concludes by highlighting the significant impact of gene editing technologies on molecular biology research. It underscores the importance of continued research and development to improve these techniques further and encourages responsible use to address ethical concerns.

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Assignment Brief 2 : Critically analyze selected scientific articles on the same subject matter, including pointing out limitations, suggesting possible improvements and appraising the impact of the scientific work and findings contained within the articles

For this assignment, you will select three scientific articles related to gene editing technologies and their applications in molecular biology. Analyze each article and provide a critical assessment, including the following points:

  • Summary: Briefly summarize the main objectives, methods, and findings of each article.
  • Strengths: Identify the strengths of each article, such as well-designed experiments, clear presentation of results, and significant contributions to the field.
  • Limitations: Point out any limitations or weaknesses in the experimental design, methodology, or data analysis that could potentially impact the validity or generalizability of the findings.
  • Possible Improvements: Suggest improvements or alternative approaches that could address the limitations and enhance the robustness of the studies.
  • Impact and Significance: Appraise the impact of each scientific work and its findings within the context of molecular biology research. Discuss potential applications and implications of the research.
  • Ethical Considerations: Analyze whether the articles address ethical considerations appropriately, especially concerning gene editing technologies.
  • Future Directions: Based on the research presented in the articles, propose potential future directions and areas of exploration for further research.

Ensure that your analysis is well-structured, supported by evidence from the articles, and critically evaluates the scientific merit of each study.

Assignment Brief 3 : Collate and critically analyze information on a given specific topic, orally present the analysis and response appropriately to questions raised

The Role of Gene Editing in Treating Genetic Disorders”

For this assignment, you are required to conduct extensive research on the role of gene editing technologies in treating genetic disorders. Collate relevant information from various scientific articles, reviews, and authoritative sources. Your oral presentation should include the following elements:

Introduction: 

Provide an overview of gene editing technologies (CRISPR-Cas9, TALENs, ZFNs) and their significance in molecular biology research.

  • Genetic Disorders: Explain different types of genetic disorders, their causes, and the challenges associated with treating them using traditional methods.
  • Gene Editing Techniques: Detail the principles and mechanisms of CRISPR-Cas9, TALENs, and ZFNs, and how they can potentially correct genetic mutations responsible for certain disorders.
  • Case Studies: Present real-world examples of gene editing applications in treating genetic disorders, such as sickle cell disease, cystic fibrosis, and muscular dystrophy.
  • Efficacy and Limitations: Analyze the success and limitations of gene editing therapies in clinical trials and animal studies. Discuss issues like off-target effects, immune responses, and ethical concerns.
  • Future Prospects: Explore ongoing research and developments in the field of gene editing for genetic disorder treatment, including potential advancements and novel approaches.
  • Ethical Considerations: Address the ethical implications of using gene editing in treating genetic disorders and the importance of responsible research and regulation.
  • Q&A Session: Be prepared to respond appropriately to questions raised by your audience about the topic.

Ensure your oral presentation is clear, well-organized, and supported by credible sources. Use visual aids if necessary to enhance understanding and engagement.

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